Does Metformin slow the progression of Autosomal Dominant Polycystic Kidney Disease?
Autosomal dominant polycystic kidney disease (ADPKD) is the 4th most common cause of kidney failure in Australia. Patients with ADPKD experience a high symptom burden including pain, anxiety, depression and poor quality of life, and yet there are very limited therapeutic options for slowing disease progression. Metformin is a safe, economical and readily-available drug which has been used to treat diabetes and polycystic ovarian syndrome. This multinational randomised trial will determine if metformin is effective at slowing cyst growth and disease progression in patients with ADPKD. Patient investigators have provided input on the trial design and will be engaged in trial conduct and implementation.